Python скрипт не выполняется из-за ошибки Mysql

cur.close()
conn.close()

Cursor closed

SHOW VARIABLES LIKE 'connect_timeout';

connect_timeout	10

interactive_timeout	28800

wait_timeout        = 43200

(2006, "MySQL server has gone away (TimeoutError(110, 'Connection timed out'))")

connect_timeout = 10
interactive_timeout = 43200
wait_timeout = 43200

#!/usr/bin/python3.8


import pymysql
import sys
from time import sleep
import datetime
import os

try:
    conn = pymysql.connect(
        user="username",
        password = "password",
        host = "hostname",
        port = 3306,
        database = "mydb"
    )
except Exception as e:
    print(f"Error connecting to MariaDB Platform: {e}")
    sys.exit(1)

cur = conn.cursor()

def period():
    try:
        sleep(3600)
        while True:
            now = datetime.datetime.now()
            now = now.hour
            if int(now) == 0:
                cur.execute("SELECT * FROM `permissions`")
                base = cur.fetchall()
                i = 0
                lan = len(base)
                while i < lan:
                    period = int(base[i][4]) - 1
                    if int(period) >= 0:
                        cur.execute("UPDATE `permissions` SET `period`='" + str(period) + "' WHERE `userID`='" + str(base[i][1])+"'")
                        conn.commit()
                        sleep(2)
                        cur.close()
                        conn.close()
                    i += 1
                os.system("reboot")
            elif int(now) == 12:
                os.system("reboot")
            sleep(60)
    except Exception as e:
        print(e)


period()